Many years ago -- at least 30 now -- when I was learning to build wheels at the shop where I worked, I built a set of wheels for my loaded touring bike on Campagnolo "flange picole" Tipo hubs, 4X to Weinmann concave rims. This was the second pair of wheels I had ever built. I am happy to report that I am still using those wheels to this day, and have never broken a spoke or had any other problems with them.
YMMV, of course.
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-John Thompson (john@os2.dhs.org)
Appleton WI USA